Table 2.

Proliferative- and differentiated-derived HepaRG ECAR parameters.

Bioenergetic parameter	Proliferative ECARsa (mpH/min/μg cellular protein)	Differentiated ECARsa (mpH/min/μg cellular protein)	Fold-Change	P-valueb (Fold-change)
Glucose-stimulated ECAR	0.84 ± 0.34	1.14 ± 0.56	0.7	0.3
ECAR capacity	7.32 ± 1.24	3.94 ± 0.78	1.9	< 0.0001
Apparent glycolytic reserve	6.48 ± 1.4	2.80 ± 0.70	2.3	< 0.001
Basal ECAR	3.97 ± 0.93	2.85 ± 0.93	1.4	0.08

^aData are presented as mean ± SD, n ≥ 5 (duplicate or triplicate from two independent experiments performed on different days with different preparations of cells).

^bP-values < 0.05 were accepted as significantly different.