Figure 6.

Regulatory model of TRPS1 during mouse early embryogenesis. During mouse preimplantation embryonic development, nuclear localization of TRPS1 (green) was most apparent in two-cell and four-cell embryos and regulated the expression of Zscan4d, MuERV-L, H3K4me3, H3K27me3, Sox2 and Oct4. The effects of TRPS1 on each of them are indicated by solid arrows (results of the present study). Dotted arrows indicate the roles of SOX2 and OCT4 that determine four-cell fate, and the roles of Zscan4d and MuERV-L in establishing two-cell like (“2C”) state in mouse embryonic stem (ES) cells.