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. 2018 Nov 7;20(4):444–453. doi: 10.1080/15384047.2018.1529119

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Figure 2. — HNF1A-AS1 knockdown suppressed OSCC cell proliferation by inducing cell apoptosis and causing cell cycle arrest. A. The high expression of HNF1-AS1 was interfered by specific shRNAs (sh-HNF1A-AS1#1, sh-HNF1A-AS1#2, and sh-HNF1A-AS1 #3). The interference efficiency was obtained at 48 hours’ post-transfection. B-C. MTT and CCK8 assays were applied to detect the effects of silenced HNF1A-AS1 on the cell proliferation of SCC-15 and Tca8113 cells. D. Colony formation assay was conducted to detect the effect of silenced HNF1A-AS1 on cell proliferation. E. The expression of ki-67 and PCNA was examined in SCC-15 and Tca8113 cells transfected with sh-HNF1A-AS1. F-G. Cell cycle distribution and cell apoptosis were analyzed in SCC-15 and Tca8113 cells transfected with sh-HNF1A-AS1. *P < 0.05, **P < 0.01 vs. control group.