Figure 3:

Differential functional connectivity in negatively correlated connections in bipolar disorder. A) Comparison of mean functional connectivity for 333 × 333 ROIs for the subjects in the study sample compared to 839 subjects of the Human Connectome Project. Shaded area represents connections with mean connectivity in HCP subjects less than zero (HCP Negatively Correlated Connections). B) Mean functional connectivity for HCP Negatively Correlated Connections for each bipolar and control subject. Boxplots show range and quartiles of each sample. C) 333 × 333 connections were divided into bins based on mean functional connectivity in the 839 HCP sample, with bin size 0.02 units of Fisher-transformed correlation. For each bin, the figure shows mean t-statistic for connections in the bin between bipolar and control samples. Error bars represent standard error of the mean for each bin. For red bins, the mean t-statistic between bipolar and control samples for connections in the bin were significantly greater than zero (Bonferroni corrected across all bins, two-tailed t-test). D) Mean functional connectivity for HCP Negatively Correlated Connections as a function of age in control, bipolar, and HCP subjects. E) Network distribution for HCP Negatively Correlated Connections. Colored squares show connections where mean functional connectivity was less than zero in the HCP sample.