Figure 12.

Representative photomicrograpghs of the granular layer (GL) and polymorphic layer (PL) of the dentate gyrus of the hippocampus showing the Nissl substances. A = control, B = corn oil (CO), C = cuprizone (CPZ), D = cuprizone then kolaviron (CPZ then Kv) and E = kolaviron then cuprizone (Kv then CPZ). A and B showed deeply stained granule cells (red arrows) of the granular layer with no chromatolytic cells. C revealed numerous chromatolytic granule cells (yellow circles) with very few adequately stained granule cells. In D and E, there were few chromatolytic cells in the granular layer (yellow circles) with few properly stained Nissl substances (red arrows) relative to A and B. Cresyl Fast Violet Stain ×400