Representative photomicrographs showing molecular layer (ML), granular layer (GL) and polymorphic layer (PL) of the dentate gyrus. A = control, B = corn oil (CO), C = cuprizone (CPZ), D = cuprizone then kolaviron (CPZ then Kv) and E = kolaviron then cuprizone (Kv then CPZ). A and B showed dense and compacted granule cells in the granular layer, while the granule cells in D was less dense than what was obtainable in A and B. C and E showed apoptotic granule cells (yellow dotted circles). H & E ×400