Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
MEK inhibitors promote G1 arrest and caspase-dependent apoptosis of MD-MSC in vitro. pERK1/2, pMEK1/2, cyclin D1, p27, and caspase-3 western blots of MD-MSC treated as indicated for (A) 5 h and (B-D) 24 h. All western blots are representative of 3–5 independent experiments. (E) Quantitation of membrane asymmetry assay of MD-MSC treated for 20 h with MEK inhibitors. Staurosporine (0.1 µM) served as a positive control for apoptosis (n = 3 independent experiments, 2-way ANOVA, *P < 0.05).
