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. 2018 Nov 28;196(1):39–51. doi: 10.1111/cei.13242

Figure 5.

Figure 5

Expression of type I interferons (IFNs) in labial salivary glands (LSGs) and Toll‐like receptor (TLR)‐7 signal activation in salivary gland epithelial cells (SGECs). (a) Representative samples showing the expressions of IFN‐α and IFN‐β in LSGs from primary Sjögren's syndrome (pSS) patients (n = 4) and non‐SS patients (n = 4). Bar: 20 μM. Insets: representative expressions of IFN‐α and IFN‐β. (b) Representative images showing the expressions of TRAF6 and IRF7 (red) in SGECs from pSS patients (n = 3). Bar: 20 μM. (c) TLR‐7 and TRAF6 signal in SGECs from pSS patients (n = 5) stimulated with 1 mM loxoribine for 6 h and/or 1000 U/ml IFN‐β for 12 h analyzed by Western blotting. * P < 0·05 by analysis of variance (anova). Error bars: standard deviation; n.s. = not significant; IRF7 = interferon regulatory factor 7.