Table 3.
Patients | No. | MSP1p19 | MSP4p40 | MSP4p30 | MSP4p20 | MSP2 | MSP3 | MSP5 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean1 | Prev2 | Mean | Prev | Mean | Prev | Mean | Prev | Mean | Prev | Mean | Prev | Mean | Prev | |||
All severe | 110 | 7·8 | 81% | 6·1 | 65% | 8·4 | 73% | 5·5 | 67% | 3·3 | 59% | 2·0 | 26% | 3·7 | 66% | |
MM | 91 | 6·5 | 53% | 4·9 | 45% | 4·5 | 40% | 4·0 | 41% | 3·0 | 32% | 2·0 | 18% | 2·6 | 33% | |
Comp. CM versus MM3 P = | 0.16 | < 10–3 | 0·12 | < 10–2 | < 10–3 | < 10–4 | 0·01 | < 10–3 | 0·13 | < 10–4 | 0·4 | 0·17 | < 10–3 | < 10–4 | ||
survival | 83 | 8·3 | 87% | 6·4 | 70% | 8·7 | 77% | 5·8 | 71% | 3·4 | 64% | 2·2 | 33% | 3·8 | 71% | |
fatal cases | 27 | 6·2 | 63% | 5·3 | 52% | 7·4 | 59% | 4·5 | 56% | 2·7 | 44% | 1·6 | 7% | 3·6 | 52% | |
Comp. surv versus fatal3 P = | 0.05 | 0·01 | 0·23 | 0·93 | 0·24 | 0·08 | 0·1 | 0·16 | 0·09 | 0·11 | 0·01 | 0·01 | 0·89 | 0·09 |
Mean and maximum (Max) levels antibody responses to merozoite antigen expressed in optical density (OD) ratio.
Prevalence (Prev) of positive antibody responses, i.e. individuals with OD ratio > 2.
Comparison of antibody levels (Mann–Whitney test) and prevalence of responders (Fisher's exact test). MSP = merozoite surface proteins; CM = cerebral malaria; MM = mild malaria.