Figure 1.

Effect of mild and moderate CCI and sham injury on HPA responsiveness to 30-min restraint stress on days 7, 34, and 70 post-injury. On days 7 and 34, tail vein samples were collected for plasma corticosterone (mean ± SEM) at baseline (time=0) and at 30, 60 and 90 min after stress onset. On day 70, trunk blood was obtained at the end of the 30-min stress period. a, p<0.01; b, p<0.05; c, p<0.05; d, p<0.05; e, p<.0001; f, p<0.05; g, p<0.01; h, p<0.05, for groups with similar letters.**, p<0.01; ***, p<0.001, for the bracketed groups. Adapted from (Taylor et al. 2008)