. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: J Surg Oncol. 2019 Mar 1;119(5):594–603. doi: 10.1002/jso.25430

Table 4.

Factors associated with failure of two-stage hepatectomy

	Regions	N	Failure number	Factors

Narita et al. ⁴⁵	Europe	80	29	1. Number of CLM in FLR ≥ 3
				2. Age > 70 yr

Giuliante et al. ⁶⁰	Europe	130	28	1. Tumor progression during chemotherapy^*

Imai et al. ⁹⁶	Europe	125	44	1. CEA > 30 ng/mL
				2. Largest CLM diameter > 4 cm
				3. Preoperative chemotherapy > 12 cycles
				4. Tumor progression during chemotherapy

Passot et al. ⁴⁸	USA	109	20	1. Number of CLM > 5
				2. Largest CLM diameter > 5 cm
				3. Preoperative chemotherapy > 6 cycles
				4. PVE
				5. Major complication after the first stage

Abbreviations: CLM, colorectal liver metastasis; FLR, future liver remnant; CEA, carcinoembryonic antigen; PVE, portal vein embolization.

Analyzed in 126 patients after excluding