Figure 4.
Schematics of mycophenolic acid (MPA) pharmacokinetic models. (A) conventional two‐compartment (2CMT) model with or without absorption lag time (Tlag), (B) continuous enterohepatic circulation (EHC) model with or without Tlag, (C) intermittent EHC model with or without Tlag. DGB, duration of gallbladder emptying; Ka, absorption rate constant; KCG, transfer rate constant from the central compartment to the gallbladder; KCP, transfer rate constant from the central compartment to the peripheral compartment; Ke, elimination rate constant; KGB, gallbladder emptying rate constant; KPC, transfer rate constant from the peripheral compartment to the central compartment; TGB, time of gallbladder emptying