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Proposed mechanism for how OG provides the drive for G4 formation in the PCNA promoter. First, OG removal by OGG1 yields a duplex-destabilizing abasic site that allows a structural switch to the G4 fold. Next, APE1 binds the abasic site when it is looped out in the G4 fold to recruit activating transcription factors for gene induction. The proposal is made on the basis of comparisons to our previous work regarding VEGF activation by a similar process.27
