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. Author manuscript; available in PMC: 2020 Mar 18.
Published in final edited form as: Chem Res Toxicol. 2019 Jan 14;32(3):437–446. doi: 10.1021/acs.chemrestox.8b00332

Figure 2.

Figure 2.

(A) The structure of a G-tetrad, in which four guanine bases associate via Hoogsteen pairing around a K+ ion, represented by the red circle. (B) A G4 representation, in which three tetrads are stacked on top of one another and stabilized by two K+ ions to adopt a parallel-stranded G4 fold. (C) The PCNA PQS showing its position in the coding strand between −126 and −159 relative to the transcription start site (TSS) of the gene.