Skip to main content
. Author manuscript; available in PMC: 2020 Mar 18.
Published in final edited form as: Chem Res Toxicol. 2019 Jan 14;32(3):437–446. doi: 10.1021/acs.chemrestox.8b00332

Figure 8.

Figure 8.

Summary of the effects of G oxidation on the PCNA G4. Oxidation to position −149 (core) destabilizes the quadruplex and leads to triplex formation, suggesting the G to be in a definitive core position. Oxidation at position −145 (loop 1) does not affect the topology of the fold, confirming it to be in a loop position, while oxidation to position −136 (loop 2) results in a conformational change, shifting the G4 from parallel to anti-parallel topology. This indicates that position −136 (loop 2) can exist in either a loop or a core position.