. Author manuscript; available in PMC: 2020 Mar 1.

Published in final edited form as: J Thorac Oncol. 2018 Dec 18;14(3):377–407. doi: 10.1016/j.jtho.2018.12.005

Table 2.

Commonly used antibodies in lung cancer

A. Markers in the differential diagnosis of carcinoma of likely lung origin

TTF1, p40 - best for daily practice

CD56, synaptophysin, chromogranin A, when NE morphology is identified

B. Markers in the differential diagnosis of adenocarcinoma (e.g. TTF1 negative/unknown primary)

TTF1, PAX8, GATA3, CDX2, CK7, CK20, (PSMA or NKX3.1 for men)

C. Markers for epithelioid undifferentiated neoplasms

Pan-cytokeratin (AE1/AE3, CAM5.2), S100, desmin, SMA, CD34, CD31, CD45

Calretinin, OCT4 (specific settings - tumor distribution, age)