Table 5.
Summary of CK7 expression in lung cancer
| Studies | Type of samples | Primary lung ADC |
Primary Lung SqCC |
Primary other NSCC | Sensitivity for ADC |
Specificity ADC |
PPV for ADC |
NPV for ADC |
|---|---|---|---|---|---|---|---|---|
| Lyda and Weiss192 | Surgical specimens | 31/33 (94%) |
8/37 (22%) | 2/6 LCNEC (33%), 5/9 LCC (56%) |
||||
| Johansson44 | Surgical specimens | 11/11 (100%) |
4/12 (33%) | 8/9 LCC/pleiomorphic Carcinoma |
||||
| Camilo et al193 | Surgical specimens | 16/17 (91%) |
1/18 (5,5%) | 3/5 LCC (60%) | ||||
| Mukhopadhyay et al39 | Biopsies versus surgical specimens |
19/19 (100%) |
9/15 (60%) | 3/4 LCC (75%) | 100% | 37% | 61% | 100% |
| Warth et al18 | TMA from surgical specimens |
509/530 (96%) |
96/456 (21%) |
47 ASC (89%), 60 LCC (71%), 31 sarcomatoid Carcinoma (68%) |
96% | 79% | 84% | 94% |
| Kimbrell et al29 | Cytology versus surgical specimens |
8/8 (100%) |
7/9 (77%) |
6/6 LCC (100%) 3/3 ASC (100%) |
||||
| Noh et al40 | TMA (poorly differentiated areas) |
32/36 (92%) |
5/38 (13%) | 6/8 LCC (75%) | 92% | 76% | 75% | 92% |
| Righi et al33 | Cellblocks (FNAC) versus surgical specimens |
66/66 (100%) |
15/24 (62%) |
10/13(1/1 ASC, 9/12 LCC and sarcomatoid carcinoma) |
100% | 92% | 92% | 100% |
| Koh et al42 | TMA from surgical specimens | 107/108 (99%) |
15/59 (25%) |
12/17 incl.4ASC, 4 pleiomorphic Carcinoma, 9 LCC |
99% | 65% | 81% | 98% |
| Gurda et al43 | Cellblocks (FNAC) | 45/48 (94%) |
7/14 (50%) | 94% | 50% | 86% | 70% | |
| Sekar et al41 | Cellblocks (FNAC) | 15/15 (100%) |
1/15 (6%) |
17/30 other NSCC (56%) | 100% | 93% | 94% | 100% |
PPV, positive predictive value (TP/TP+FP); NPV, negative predictive value (TN/TN+FN); ADC, adenocarcinoma; SqCC, Squamous cell carcinoma; ASC, Adenosquamous carcinoma; LCNEC, large cell neuroendocrine carcinoma; LCC, large cell carcinoma; TMA, tissue microarrays; FNAC, fine needle aspiration cytology