Table 8.
Immunoprofiles of pulmonary mucinous adenocarcinomas and their mimics*
| TTF1 | Napsin-A6) | CK7 | CK20 | CDX2 | |
|---|---|---|---|---|---|
| Pulmonary adenocarcinomas | |||||
| Invasive mucinous adenocarcinoma1) | −/+ | −/+ | ++ | +/− | +/− |
| Colloid adenocarcinoma | +/− | +/− | + | +/− | + |
| Signet ring cell carcinoma2) | + | +/− | ++ | − | − |
| Solid adenocarcinoma with mucin | + | +/− | ++ | − | − |
| Mucinous adenocarcinoma of the lung, NOS3) | +/− | −/+ | ++ | −/+ | −/+ |
| Non-pulmonary adenocarcinomas | |||||
| GI tract all | − | − | +/− | + | + |
| Lower GI tract4) | − | − | −/+ | ++ | ++ |
| Upper GI tract5) | − | − | + | +/− | +/− |
| Pancreas | − | − | ++ | +/− | +/− |
| Breast, mucinous | − | − | ++ | − | − |
| Ovary, mucinous | − | − | ++ | +/− | +/− |
-: <10%, −/+: 10–40%, +/−: 40–70%, +: 70–90%, ++: >90% of examined tumors exhibited positive expression
1)
including mixed mucinous sand non-mucinous adenocarcinoma
2)
adenocarcinoma with signet ring cell features
3)
NOS: not otherwise specified
4)
colorectum and appendix
5)
esophagus, stomach and ampulla
6)
immunohistochemistry with monoclonal Napsin-A antibodies