Table 2.
Summary of outcomes in definitive chemoradiotherapy group
| Authors | Year | N | Grade 3/4 toxicities (%) | Fistula formation (%) | Mortality (%) | Response rate (%) | cCR rate (%) | 1/3/5‐year overall survival rate (%) | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Acute | Late | cCR | Non‐cCR | |||||||
| Satake et al33 | 2016 | 33c |
24c (leukocytopenia) 18c (neutropenia) 15c (dysphagia) |
NA | 6c | 0c | 73 | 39c | NA | NA |
| Jingu et al34 | 2016 | 70 |
44c (leukocytopenia) 17c (esophagitis) |
3c (pneumonitis) | 5c | 7c | NA | NA | NA | NA |
| Li et al40 | 2016 | 56 | 25 (leukocytopenia) | NA | 11 | 9 | 61 | 23 | 92/55/NA | NA |
| Miyazaki et al35 | 2015 | 37a |
92c (leukocytopenia) 76c (neutropenia) 32c (nausea) |
NA | 5 | 0 | 86 | 48 | NA | NA |
| Shinoda et al36 (JCOG0303) | 2015 |
71c (LDCF) 71c (SDCF) |
29c (dysphagia/esophagitis) 21c (leukocytopenia) 21c (anorexia) 26c (leukocytopenia) 23c (dysphagia/esophagitis) 20c (anorexia) |
22c (fistula) 18c (dyspnea) 10c (dysphagia) 18c (fistula) 14c (dyspnea) 11c (dysphagia) |
22c
18c |
1c
3c |
NA NA |
1c
0c |
NA NA |
NA NA |
| Higuchi et al37 (KDOG0501‐P2) | 2014 | 42c |
71c (leukocytopenia) 57c (neutropenia) 38c (febrile neutropenia) |
8c (esophagitis /stenosis/fistula) |
5c | 2c | 86c | 52c | NA | NA |
| Seto et al12 | 2007 | 29 | NA | 0 | NA | 0 | NA | 24 | 83/33/33 | 23/0/0 |
| Font et al14 | 2007 | 19 | 17b (esophagitis) | NA | NA | 6b | NA | NA | NA | NA |
| Fujita et al13 | 2005 | 23 |
30a (leukocytopenia) 13a (anemia) |
NA | NA | NA | 57 | 39 | NA | NA |
| Ishida et al38 (JCOG9516) | 2004 | 60c |
33c (leukocytopenia) 10c (liver dysfunction) |
NA | NA | 3c | 68c | 15c | NA | NA |
| Crosby et al15 | 2004 | 27 |
12b (oral mucositis) 10b (leukocytopenia) |
NA | NA | 0 | NA | NA | NA | NA |
| Kaneko et al16 | 2003 | 35 |
33b (anemia) 30b (leukocytopenia) 25b (esophagitis) |
0 | 9 | 6 | NA | 29 | NA | NA |
| Nishimura et al19 | 2002 | 23 |
50 (leukocytopenia) 32 (dysphagia) 21 (anemia) 11 (thrombocytopenia) |
NA | 18 | 7 | 88 | 32 | NA | NA |
| Itoh et al17 | 2001 | 35 | NA | NA | NA | NA | 68 | 17 | 83/25/25 | 26/7/0 |
| Ohtsu et al18 | 1999 | 36 |
28c (anemia) 24c (leukocytopenia) 17c (thrombocytopenia) 15c (esophagitis) |
NA | 14 | 7c | 81 | 25 | NA | NA |
| Ohtsu et al39 | 1995 | 20c | 45c (leukocytopenia) | NA | 20c | 10c | 85c | 30c | NA | NA |
Data in patients including aChemoradiotherapy (CRT) and CRT plus surgery group, bT3/4 tumors, or cT4/M1 lym tumors. cCR, clinical complete response; CR, complete response; LDCF, low‐dose cisplatin and 5‐fluorouracil; NA, data not available; SDCF, standard‐dose cisplatin and 5‐fluorouracil.