Table 2.
Univariate and multivariate logistic regression analysis for END
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | |
| Select variables | ||||
| Age | 1.024 (1.008–1.142) | 0.044 | ||
| Female | 1.322 (0.901–1.996) | 0.148 | ||
| Hypertension | 0.801 (0.529–1.212) | 0.294 | ||
| Diabetes mellitus | 1.069 (0.664–1.721) | 0.783 | ||
| Hyperlipidemia | 0.676 (0.383–1.190) | 0.175 | ||
| Current drinking | 1.059 (0.622–1.695) | 0.811 | ||
| Current smoking | 1.353 (0.885–2.070) | 0.163 | ||
| Atrial fibrillation | 0.962 (0.550–1.681) | 0.891 | ||
| Previous antiplatelet | 1.157 (0.693–1.932) | 0.576 | ||
| Previous statin | 1.123 (0.590–2.136) | 0.724 | ||
| Body mass index | 1.083 (1.019–1.151) | 0.012 | ||
| Systolic blood pressure | 1.007 (0.996–1.017) | 0.201 | ||
| Diastolic blood pressure | 1.019 (1.000–1.038) | 0.049 | ||
| NIHSS score | 1.027 (0.986–1.069) | 0.203 | ||
| Silent lacunar infarction | 1.206 (0.811–1.796) | 0.355 | ||
| White matter lesions | 1.737 (1.144–2.638) | 0.010 | ||
| Hs‐CRP | 1.004 (0.980–1.020) | 0.992 | ||
| Fasting blood glucose | 1.117 (1.011–1.234) | 0.030 | ||
| Homocysteine | 1.037 (1.007–1.067) | 0.016 | ||
| 25(OH)D level | ||||
| As continuous variable | 0.976 (0.961–0.987) | 0.001 | 0.973 (0.958–0.991) | 0.005 |
| As categorical variable | ||||
| Fourth quartile | Reference | Reference | ||
| Third quartile | 1.248 (0.938–3.774) | 0.108 | 1.188 (0.540–2.615) | 0.664 |
| Second quartile | 2.789 (1.492–5.211) | 0.006 | 1.925 (0.922–4.021) | 0.081 |
| First quartile | 3.237 (1.731–6.054) | 0.001 | 2.622 (1.226–5.641) | 0.015 |
Notes. 25(OH)D: 25‐hydroxyvitamin D; CI: confidence interval; END: early neurological deterioration; Hs‐CRP: hyper‐sensitive C‐reactive protein; NIHSS: national institute of health stroke scale; OR: odds ratio.
Multivariate analysis adjusted for age, sex, white matter lesions, body mass index, diastolic blood pressure, fasting blood glucose and homocysteine level.