TABLE 3.

Pulmonary function tests results

Pulmonary function test	PBI-4050 alone	PBI-4050+nintedanib	PBI-4050+pirfenidone
Patients n	9	16	15
FVC % pred
Baseline
Mean±sd	83.11±17.37	71.31±17.05	70.80±14.82
Median	79.0	69.0	68.0
Range	58.0–109.0	45.0–107.0	45.0–100.0
Week 12
Mean±sd	82.00±16.57	71.38±15.98	68.11±15.79
Median	74.0	69.5	64.0
Range	56.0–105.0	51.0–98.0	39.0–101.0
Change from baseline at week 12
Mean±sd	−1.11±4.46	0.06±4.02	−2.69±4.11
Median	−1.0	1.0	−4.0
95% CI	−4.5–2.3	−2.1–2.2	−5.00–−0.4
p-value#	0.4759	0.9513	0.0240
FVC mL
Baseline
Mean±sd	2884±759.59	2761±530.03	2849±745.62
Median	2650	2735	2930
Range	1750–4380	1290–3480	1580–4280
Week 12
Mean±sd	2872±811.82	2763±520.70	2747±813.67
Median	2770	2775	2720
Range	1640–4330	1430–3440	1470–4360
Change from baseline at week 12
Mean±sd	−12.2±137.1	1.9±127.6	−102±137.8
Median	−50.0	25.0	−140
95% CI	−117.6–93.2	−66.1–69.9	−178.3–−25.7
p-value#	0.7959	0.9539	0.0124
DLCO % pred
Baseline
Mean±sd	45.22±11.62	50.75±14.81	49.07±16.33
Median	47.0	53.0	45.0
Range	27.0–64.0	24.0–70.0	23.0–83.0
Week 12
Mean±sd	41.22±11.20	49.25±14.03	46.53±18.10
Median	41.0	49.5	45.0
Range	26.0–56.0	22.0–72.0	18.0–83.0
Change from baseline at week 12
Mean±sd	−4.00±7.4	−1.50±3.5	−2.54±6.3
Median	−3.0	−3.0	0.0
95% CI	−9.7–1.7	−3.4–0.37	−6.0–0.9
p-value#	0.1427	0.1073	0.1390

FVC: forced vital capacity; % pred: % predicted; D_LCO: diffusing capacity of the lung for carbon monoxide. ^#: p-value based on paired t-test.