TABLE 2.
Risk of occult N2 disease according to each definition of a centrally located tumour in patients with radiological N0 nonsmall cell lung cancer
| Definition of central location | Patients n (%) | Crude model | Model 1# | Model 2¶ | |||
| Unadjusted OR (95% CI) | p-value | Adjusted OR (95% CI) | p-value | Adjusted OR (95% CI) | p-value | ||
| Contact with the hilar structure | 122 (9.1) | 1.86 (1.02−3.40) | 0.042 | 1.16 (0.59−2.29) | 0.671 | 1.26 (0.63−2.54) | 0.510 |
| Concentric lines arising from the hilum | |||||||
| Inner one-third | 216 (16.2) | 1.91 (1.17–3.11) | 0.010 | 1.29 (0.75–2.23) | 0.358 | 1.33 (0.77–2.31) | 0.311 |
| Inner two-thirds | 642 (48.0) | 1.54 (1.01–2.37) | 0.046 | 1.09 (0.68–1.73) | 0.730 | 1.06 (0.66–1.70) | 0.808 |
| Concentric lines arising from the midline | |||||||
| Inner one-third | 161 (12.0) | 2.63 (1.59−4.36) | <0.001 | 2.05 (1.14−3.71) | 0.017 | 2.13 (1.17−3.87) | 0.013 |
| Inner two-thirds | 696 (52.1) | 2.03 (1.29−3.18) | 0.002 | 1.50 (0.92−2.46) | 0.104 | 1.48 (0.90−2.42) | 0.121 |
| Sagittal lines arising from the midline | |||||||
| Inner one-third | 358 (26.8) | 1.81 (1.17−2.80) | 0.008 | 1.57 (0.90−2.73) | 0.113 | 1.59 (0.91−2.79) | 0.101 |
| Inner two-thirds | 1073 (80.3) | 1.30 (0.74−2.30) | 0.365 | 0.89 (0.49−1.63) | 0.712 | 0.90 (0.49−1.64) | 0.721 |
#: adjusted for tumour size (continuous) and tumour attenuation on computed tomography (tumour histology and number of dissected nodes and stations during mediastinal lymph node dissection were not included since this information was not available pre-operatively); ¶: further adjusted for age (continuous), sex, smoking history (never-smoker or ever-smoker) and lobar location (right or left) of tumour.