| 1 Emotionalism |
4 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 1.1 50% reduction in emotionalism |
1 |
19 |
Risk Ratio (M‐H, Random, 95% CI) |
16.5 [1.07, 253.40] |
| 1.2 Improved score on Lability scale (House 1989 measure) |
1 |
28 |
Risk Ratio (M‐H, Random, 95% CI) |
1.44 [0.95, 2.19] |
| 1.3 Clinician interview‐based impression of change ‐ improved score |
1 |
28 |
Risk Ratio (M‐H, Random, 95% CI) |
1.44 [0.95, 2.19] |
| 1.4 Diminished tearfulness |
3 |
164 |
Risk Ratio (M‐H, Random, 95% CI) |
2.18 [1.29, 3.71] |
| 2 Emotionalism: mean scores at end of treatment |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 2.1 Pathological Laughter and Crying Scale (high score = worse emotionalism) |
1 |
28 |
Mean Difference (IV, Fixed, 95% CI) |
‐8.4 [‐11.56, ‐5.24] |
| 3 Depression: 1. Mean scores at end of treatment |
2 |
72 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.82 [‐2.14, 0.51] |
| 3.1 Hamilton Depression Rating Scale (high score = more depressed) |
1 |
28 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.53 [‐2.39, ‐0.67] |
| 3.2 Montgomery Asberg Depression Rating Scale (high score = more depressed) |
1 |
44 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.18 [‐0.77, 0.42] |
| 4 Depression: 2. Average change in scores between baseline and end of treatment |
2 |
72 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.05 [‐0.72, 0.62] |
| 4.1 Hamilton Depression Rating Scale (high score = more depressed) |
1 |
28 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.43 [‐1.18, 0.32] |
| 4.2 Montgomery Asberg Depression Rating Scale (high score = more depressed) |
1 |
44 |
Std. Mean Difference (IV, Random, 95% CI) |
0.26 [‐0.34, 0.85] |
| 5 Cognitive functioning: mean scores at end of treatment |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 5.1 Mini‐mental state examination (low score = cognitive impairment) |
1 |
28 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.30 [‐3.27, 2.67] |
| 6 Activities of daily living: 1. Mean scores at end of treatment |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 6.1 Johns Hopkins Functioning Inventory (high score = worse function) |
1 |
28 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.40 [‐5.22, 2.42] |
| 7 Adverse events: 1. Death |
6 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 7.1 At end of treatment |
6 |
172 |
Risk Ratio (M‐H, Random, 95% CI) |
0.59 [0.08, 4.50] |
| 8 Adverse events: 2. All |
2 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 8.1 Central nervous system events (e.g. confusion, sedation, tremor) |
2 |
56 |
Risk Ratio (M‐H, Random, 95% CI) |
1.0 [0.11, 9.08] |
| 8.2 Gastrointestinal effects (e.g. constipation, diarrhoea) |
1 |
28 |
Risk Ratio (M‐H, Random, 95% CI) |
0.33 [0.01, 7.55] |
| 8.3 Other events not listed above (e.g. dysuria, eye discomfort) |
1 |
28 |
Risk Ratio (M‐H, Random, 95% CI) |
5.0 [0.26, 95.61] |
| 8.4 Recurrent stroke |
1 |
28 |
Risk Ratio (M‐H, Random, 95% CI) |
1.0 [0.07, 14.45] |
| 9 Adverse events: 3. Leaving the study early (including death) |
5 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 9.1 All dropouts and withdrawals |
5 |
216 |
Risk Ratio (M‐H, Random, 95% CI) |
1.17 [0.38, 3.58] |
