Study	Reason for exclusion
Aizawa 1977	Methods: double‐blind RCT Participants: cerebrovascular disorders (including arteriosclerosis) Intervention: cyclandelate for 4 weeks Outcomes: data not currently available for those with 'emotionalism' at baseline
Allen 2018	Methods: not a RCT, i.e. non‐interventional, cross‐sectional, case control study Participants: nursing home residents with documented diagnosis of pseudobulbar affect Intervention: dextromethorphan/quinidine
Atarashi 1988	Methods: randomisation unclear Participants: stroke, including cerebral arteriosclerosis Intervention: no placebo comparison
Bassi 1984	Methods: non‐random, open‐label Participants: chronic cerebrovascular disorders Intervention: no placebo comparison
Chen 2010	Methods: not a RCT, i.e. case report and literature review Intervention: quetiapine
Colamonico 2012	Methods: not a RCT, i.e. survey of to estimate the impact or burden of pseudobulbar affect
D'Amico 2017	Methods: non‐random, open‐label
Doody 2014	Participants: ineligible study population, i.e. participants were adults who had pseudobulbar affect after being diagnosed with dementia/Alzheimer's Disease
Formella 2017a	Methods: non‐random, open‐label
Formella 2017b	Methods: non‐random, open‐label
Kim 2017a	Outcomes: data not currently available for those with 'emotionalism' at baseline pretreatment
Kim 2017b	Methods: not a RCT, i.e. review of the most common poststroke mood and emotional disturbances
Lawson 1969	Methods: randomised Participants: hypertensive or ischaemic cerebral disease (number with stroke unclear) Intervention: method of randomisation makes placebo comparison ineffectual ‐ no appropriate washout period
Manzo 1998	Methods: not a RCT, i.e. qualitative study of pseudobulbar affect
Moller 2007	Methods: randomised Participants: patients with stroke and pathological crying Intervention: citalopram for 30 days Outcomes: emotionalism not investigated
Muller 1999	Methods: quasi‐randomised, 2 active treatments Participants: brain injury Intervention: no placebo comparison
Narushima 2002	Methods: double‐blind, randomised Participants: poststroke Intervention: prevention of depression Outcomes: emotionalism not investigated
Ohtomo 1985	Methods: double‐blind, randomised Participants: cerebrovascular disorders, including arteriosclerosis Intervention: tiapride for 5 weeks Outcomes: data not currently available for those with 'emotionalism' at baseline
Otomo 1984	Methods: double‐blind, randomised Participants: cerebrovascular disorders Outcomes: emotionalism not investigated
Rasmussen 2000	Methods: double‐blind, randomised Participants: poststroke without depression, emotionalism not assessed at baseline
Sauve 2017	Participants: ineligible study population, i.e. participants were adults who had pseudobulbar affect after being diagnosed with dementia/Alzheimer's Disease
Schiffer 1985	Methods: double‐blind, cross‐over Participants: ineligible study population, i.e. multiple sclerosis (not stroke)
Seliger 1992	Method: non‐random, open‐label Participants: patients with stroke or multiple sclerosis (not stroke) and emotional incontinence
Udaka 1984	Methods: non‐random, open‐label Participants: ineligible study population, i.e. diffuse cerebrovascular disease (not stroke)
Work 2011	Methods: not a RCT, i.e. a survey to estimate the overall prevalence of pseudobulbar affect and quantify the extent to which it is diagnosed and treated
Yang 2015	Methods: not a RCT, i.e. a literature review Participants: adults with pseudobulbar affect Intervention: dextromethorphan/quinidine

RCT: randomised controlled trial