Table 2. The association of lncRNA MALAT1 polymorphisms and CAD risk stratified by host characteristics.
| Variables | Genotype | CAD compared with CON | P1 | OR (95% CI) |
|---|---|---|---|---|
| MALAT1 rs4102217 | ||||
| Gender | ||||
| Male | GG | 189/201 | 1 (Ref) | |
| GC | 65/58 | 0.319 | 1.23 (0.82–1.84) | |
| CC | 6/7 | 0.871 | 0.91 (0.30–2.76) | |
| CC+GC compared with GG | 0.372 | 1.19 (0.81–1.76) | ||
| CC compared with GC+GG | 0.799 | 0.87 (0.29–2.61) | ||
| Female | GG | 54/74 | 1 (Ref) | |
| GC | 27/20 | 0.072 | 1.86 (0.95–3.68) | |
| CC | 2/4 | 0.696 | 0.71 (0.12–4.03) | |
| CC+GC compared with GG | 0.121 | 1.67 (0.87–3.18) | ||
| CC compared with GC+GG | 0.545 | 0.59 (0.11–3.30) | ||
| Age (years) | ||||
| ≤60 | GG | 149/162 | 1 (Ref) | |
| GC | 53/44 | 0.251 | 1.31 (0.83–2.07) | |
| CC | 8/6 | 0.487 | 1.47 (0.50–4.37) | |
| CC+GC compared with GG | 0.198 | 1.33 (0.86–2.06) | ||
| CC compared with GC+GG | 0.529 | 1.42 (0.48–4.18) | ||
| >60 | GG | 94/113 | 1 (Ref) | |
| GC | 41/34 | 0.164 | 1.47 (0.86–2.53) | |
| CC | 0/5 | NA | NA | |
| CC+GC compared with GG | 0.361 | 1.28 (0.76–2.17) | ||
| CC compared with GC+GG | NA | NA | ||
| Smoking | ||||
| Ever smoker | GG | 168/144 | 1 (Ref) | |
| GC | 58/63 | 0.298 | 1.28 (0.80–2.04) | |
| CC | 7/4 | 0.568 | 1.45 (0.41–5.11) | |
| CC+GC compared with GG | 0.257 | 1.30 (0.83–2.03) | ||
| CC compared with GC+GG | 0.627 | 1.37 (0.39–4.80) | ||
| Never smoker | GG | 75/131 | 1 (Ref) | |
| GC | 36/39 | 0.080 | 1.62 (0.94–2.77) | |
| CC | 1/7 | 0.185 | 0.24 (0.03–1.99) | |
| CC+GC compared with GG | 0.205 | 1.40 (0.83–2.36) | ||
| CC compared with GC+GG | 0.146 | 0.21 (0.03–1.72) | ||
| Alcohol drinking | ||||
| Drinker | GG | 65/151 | 1 (Ref) | |
| GC | 24/50 | 0.780 | 1.09 (0.61–1.92) | |
| CC | 2/5 | 0.909 | 1.11 (0.20–6.20) | |
| CC+GC compared with GG | 0.787 | 1.08 (0.62–1.88) | ||
| CC compared with GC+GG | 0.986 | 1.02 (0.19–5.49) | ||
| Non-drinker | GG | 178/124 | 1 (Ref) | |
| GC | 70/28 | 0.010 | 1.96 (1.17–3.28) | |
| CC | 6/6 | 0.557 | 0.70 (0.21–2.30) | |
| CC+GC compared with GG | 0.026 | 1.73 (1.07–2.79) | ||
| CC compared with GC+GG | 0.396 | 0.60 (0.18–1.96) | ||
| HBP | ||||
| Yes | GG | 135/89 | 1 (Ref) | |
| GC | 54/23 | 0.168 | 1.48 (0.85–2.60) | |
| CC | 4/2 | 0.945 | 1.07 (0.18–6.23) | |
| CC+GC compared with GG | 0.173 | 1.46 (0.85–2.52) | ||
| CC compared with GC+GG | 0.941 | 1.07 (0.19–6.05) | ||
| NO | GG | 107/186 | 1 (Ref) | |
| GC | 40/55 | 0.383 | 1.24 (0.77–2.00) | |
| CC | 4/9 | 0.647 | 0.75 (0.22–2.57) | |
| CC+GC compared with GG | 0.498 | 1.17 (0.74–1.85) | ||
| CC compared with GC+GG | 0.611 | 0.73 (0.22–2.45) | ||
| DM | ||||
| Yes | GG | 62/39 | 1 (Ref) | |
| GC | 29/5 | 0.010 | 4.07 (1.41–11.81) | |
| CC | 0/1 | NA | NA | |
| CC+GC compared with GG | 0.019 | 3.29 (1.22-8.88) | ||
| CC compared with GC+GG | NA | NA | ||
| No | GG | 181/235 | 1 (Ref) | |
| GC | 65/73 | 0.412 | 1.18 (0.80–1.74) | |
| CC | 8/10 | 0.884 | 1.07 (0.41–2.81) | |
| CC+GC compared with GG | 0.426 | 1.16 (0.80–1.69) | ||
| CC compared with GC+GG | 0.963 | 1.02 (0.40–2.65) | ||
| LDL | ||||
| High | GG | 44/56 | 1 (Ref) | |
| GC | 14/16 | 0.787 | 1.12 (0.49–2.59) | |
| CC | 2/2 | 0.801 | 1.29 (0.18–9.59) | |
| CC+GC compared with GG | 0.732 | 1.15 (0.52–2.54) | ||
| CC compared with GC+GG | 0.819 | 1.26 (0.17–9.26) | ||
| Normal | GG | 174/211 | 1 (Ref) | |
| GC | 65/60 | 0.183 | 1.32 (0.88–1.98) | |
| CC | 5/9 | 0.489 | 0.68 (0.22–2.06) | |
| CC+GC compared with GG | 0.293 | 1.23 (0.83–1.82) | ||
| CC compared with GC+GG | 0.414 | 0.63 (0.21–1.91) | ||
| Low | GG | 12/6 | 1 (Ref) | |
| GC | 8/2 | 0.564 | 1.84 (0.23–14.68) | |
| CC | 0/0 | NA | NA | |
| CC+GC compared with GG | 0.564 | 1.84 (0.23–14.68) | ||
| CC compared with GC+GG | NA | NA | ||
| MALAT1 rs619586 | ||||
| Gender | ||||
| Male | AA | 225/223 | 1 (Ref) | |
| AG | 33/36 | 0.699 | 0.91 (0.54–1.50) | |
| GG | 1/1 | 0.923 | 1.15 (0.07–18.62) | |
| GG+AG compared with AA | 0.709 | 0.91 (0.55–1.50) | ||
| GG compared with AG+AA | 0.956 | 1.08 (0.07-17.50) | ||
| Female | AA | 68/86 | 1 (Ref) | |
| AG | 17/10 | 0.069 | 2.19 (0.94–5.11) | |
| GG | 0/1 | NA | NA | |
| GG+AG compared with AA | 0.103 | 1.99 (0.87–4.53) | ||
| GG compared with AG+AA | NA | NA | ||
| Age (years) | ||||
| ≤60 | AA | 175/184 | 1 (Ref) | |
| AG | 29/25 | 0.487 | 1.23 (0.69–2.18) | |
| GG | 1/1 | 0.993 | 1.01 (0.06–16.35) | |
| GG+AG compared with AA | 0.493 | 1.22 (0.69–2.15) | ||
| GG compared with AG+AA | 0.990 | 1.02 (0.06–16.40) | ||
| >60 | AA | 118/125 | 1 (Ref) | |
| AG | 21/21 | 0.898 | 1.04 (0.54–2.01) | |
| GG | 0/1 | NA | NA | |
| GG+AG compared withAA | 0.995 | 1.00 (0.52–1.91) | ||
| GG compared with AG+AA | NA | NA | ||
| Smoking | ||||
| Ever smoker | AA | 205/159 | 1 (Ref) | |
| AG | 30/24 | 0.983 | 0.99 (0.56–1.77) | |
| GG | 1/1 | 0.949 | 0.91 (0.06–14.86) | |
| GG+AG compared with AA | 0.970 | 0.99 (0.56–1.75) | ||
| GG compared with AG+AA | 0.928 | 0.88 (0.05–14.28) | ||
| Never smoker | AA | 88/150 | 1 (Ref) | |
| AG | 20/22 | 0.186 | 1.57 (0.81–3.05) | |
| GG | 0/1 | NA | NA | |
| GG+AG compared with AA | 0.235 | 1.49 (0.77–2.89) | ||
| GG compared with AG+AA | NA | NA | ||
| Alcohol drinking | ||||
| Drinker | AA | 78/174 | 1 (Ref) | |
| AG | 13/26 | 0.800 | 1.10 (0.53–2.26) | |
| GG | 0/1 | NA | NA | |
| GG+AG compared with AA | 0.884 | 1.06 (0.52–2.16) | ||
| GG compared with AG+AA | NA | NA | ||
| Non-drinker | AA | 215/135 | 1 (Ref) | |
| AG | 37/20 | 0.481 | 1.24 (0.68–2.27) | |
| GG | 1/1 | 0.834 | 0.74 (0.04–12.70) | |
| GG+AG compared with AA | 0.515 | 1.22 (0.67–2.20) | ||
| GG compared with AG+AA | 0.800 | 0.69 (0.04–11.75) | ||
| HBP | ||||
| Yes | AA | 165/90 | 1 (Ref) | |
| AG | 31/16 | 0.957 | 1.02 (0.53–1.98) | |
| GG | 0/2 | NA | NA | |
| GG+AG compared with AA | 0.758 | 0.90 (0.48–1.72) | ||
| GG compared with AG+AA | NA | NA | ||
| No | AA | 127/219 | 1 (Ref) | |
| AG | 19/30 | 0.814 | 1.08 (0.58–2.01) | |
| GG | 1/0 | NA | NA | |
| GG+AG compared with AA | 0.695 | 1.13 (0.61–2.09) | ||
| GG compared with AG+AA | NA | NA | ||
| DM | ||||
| Yes | AA | 71/39 | 1 (Ref) | |
| AG | 17/7 | 0.778 | 1.15 (0.43–3.12) | |
| GG | 0/0 | NA | NA | |
| GG+AG compared with AA | 0.778 | 1.15 (0.43–3.12) | ||
| GG compared with AG+AA | NA | NA | ||
| No | AA | 222/269 | 1 (Ref) | |
| AG | 33/39 | 0.997 | 1.00 (0.61–1.65) | |
| GG | 1/2 | 0.802 | 0.73 (0.07–8.22) | |
| GG+AG compared with AA | 0.959 | 0.99 (0.60–1.61) | ||
| GG compared with AG+AA | 0.768 | 0.70 (0.06–7.78) | ||
| LDL | ||||
| High | AA | 56/54 | ||
| AG | 6/15 | 0.065 | 0.38 (0.14–1.06) | |
| GG | 1/1 | 0.936 | 0.89 (0.05–14.86) | |
| GG+AG compared with AA | 0.072 | 0.41 (0.16–1.08) | ||
| GG compared with AG+AA | 1.000 | 1.00 (0.06–16.55) | ||
| Normal | AA | 204/246 | ||
| AG | 36/29 | 0.128 | 1.50 (0.89–2.54) | |
| GG | 0/1 | NA | NA | |
| GG+AG compared with AA | 0.159 | 1.46 (0.86–2.45) | ||
| GG compared with AG+AA | NA | NA | ||
| Low | AA | 16/6 | ||
| AG | 4/2 | 0.782 | 0.74 (0.09–8.37) | |
| GG | 0/0 | NA | NA | |
| GG+AG compared with AA | 0.782 | 0.74 (0.09–6.37) | ||
| GG compared with AG+AA | NA | NA |
Abbreviations: CON, control; HBP, high blood pressure; LDL, low-density lipoprotein.
1Using Logistic Regression adjusted by gender and age.
Values in bold represent statistical significance.