Table 4. The interaction of three MALAT1 polymorphisms with environmental factors in CAD risk.
| Smoking | Drinking | ||||
|---|---|---|---|---|---|
| Never Smoker | Ever Smoker | Non-drinker | Drinker | ||
| MALAT1 rs4102217 | |||||
| GG | Case/control | 75/131 | 168/144 | 178/124 | 65/151 |
| OR (95% CI) | 1 (Ref) | 2.04 (1.42–2.92) | 1 (Ref) | 0.30 (0.21–-0.43) | |
| CC+GC | Case/control | 37/46 | 65/43 | 76/34 | 26/55 |
| OR (95% CI) | 1.41 (0.84–2.36) | 2.64 (1.64–4.26) | 1.56 (0.98–2.48) | 0.33 (0.20–0.55) | |
| Pinteraction=0.825 | Pinteraction=0.207 | ||||
| OR = 0.93, 95% CI = 0.47–1.84 | OR = 0.624, 95% CI = 0.30–1.30 | ||||
| MALAT1 rs619586 | |||||
| AA | Case/control | 88/150 | 205/19 | 215/135 | 78/174 |
| OR (95% CI) | 1 (Ref) | 2.20 (1.57–3.07) | 1 (Ref) | 0.22 (0.10–0.48) | |
| GG+AG | Case/control | 20/23 | 31/25 | 38/21 | 13/27 |
| OR (95% CI) | 1.48 (0.77–2.85) | 2.11 (1.17–3.81) | 1.41 (0.84–2.37) | 0.38 (0.22–0.65) | |
| Pinteraction=0.355 | Pinteraction=0.753 | ||||
| OR = 0.66, 95% CI = 0.28–1.58 | OR = 0.86, 95% CI = 0.34–2.18 | ||||
P for interaction used logistic regession adjusted by gender, age.