Table 5. Gene–gene interaction models for MALAT1 two polymorphisms for CAD risk by MDR analysis.

Model	Training Bal. Acc.	Testing Bal. Acc.	Sign Test (P)	CV Consistency	P for permutation test
Drinking	0.6598	0.6601	10 (0.0010)	10/10	0.0000–0.0010
Smoking-Drinking	0.6790	0.6789	10 (0.0010)	10/10	0.0000–0.0010
MALAT1 rs4102217-smoking-drinking1	0.6995	0.6979	10 (0.0010)	10/10	0.0000–0.0010
MALAT1 rs4102217-MALAT1 rs619586-smoking-drinking	0.7054	0.6900	10 (0.0010)	10/10	0.0000–0.0010

The best model was selected as the one with the maximum testing accuracy and maximum CV consistency.

¹In this study, the best interaction model was the three-factor model including MALAT1 rs4102217 polymorphism-smoking-drinking.