Table 7. The association of MALAT1 SNPs and clinical features.
| Variation | Wild-type | Mutated-type | Wild-type | Mutated-type | P |
|---|---|---|---|---|---|
| MALAT1 rs4102217 | |||||
| Smoking | P=0.327 | ||||
| No | 75 (30.9) | 37 (36.3) | / | / | / |
| Yes | 168 (69.1) | 65 (63.7) | / | / | / |
| Drinking | P=0.809 | ||||
| No | 178 (73.3) | 76 (74.5) | / | / | / |
| Yes | 65 (26.7) | 26 (25.5) | / | / | / |
| HBP | P=0.854 | ||||
| No | 107 (44.2) | 44 (43.1) | / | / | / |
| Yes | 135 (55.8) | 58 (56.9) | / | / | / |
| Diabetes | P=0.575 | ||||
| No | 181 (74.5) | 73 (71.6) | / | / | / |
| Yes | 62 (25.5) | 29 (28.4) | / | / | / |
| Cerebrovascular disease | P=0.570 | ||||
| No | 208 (86.0) | 90 (88.2) | / | / | / |
| Yes | 34 (14.0) | 12 (11.8) | / | / | / |
| Hyperlipidemia | P=0.521 | ||||
| No | 114 (46.9) | 44 (43.1) | / | / | / |
| Yes | 129 (53.1) | 58 (56.9) | / | / | / |
| Blood Glucose | P=0.747 | 8.20 ± 4.14 | 8.53 ± 5.10 | 0.538 | |
| Normal | 80 (33.8) | 32 (31.7) | |||
| High | 156 (65.8) | 69 (68.3) | |||
| Low | 1 (0.4) | 0 (0) | |||
| Total cholesterol | P=0.719 | 4.43 ± 1.19 | 4.55 ± 1.21 | 0.385 | |
| Normal | 178 (77.4) | 71 (75.5) | |||
| High | 52 (22.6) | 23 (24.5) | |||
| Triacylglyceride | P=0.373 | 1.90 ± 1.58 | 2.29 ± 2.58 | 0.168 | |
| Normal | 193 (83.9) | 75 (79.8) | |||
| High | 37 (16.1) | 19 (20.2) | |||
| High-density lipoprotein | P=0.846 | 0.99 ± 0.27 | 0.98 ± 0.29 | 0.708 | |
| Normal | 105 (45.7) | 46 (48.9) | |||
| High | 2 (0.9) | 1 (1.1) | |||
| Low | 123 (53.5) | 47 (50.0) | |||
| Low-density lipoprotein | P=0.510 | 2.94 ± 1.05 | 2.91 ± 0.84 | 0.795 | |
| Normal | 174 (75.7) | 70 (74.5) | |||
| High | 44 (19.1) | 16 (17.0) | |||
| Low | 12 (5.2) | 8 (8.5) | |||
| Urea nitrogen | P=0.980 | 6.27 ± 3.47 | 6.44 ± 5.18 | 0.732 | |
| Normal | 213 (89.1) | 91 (89.2) | |||
| High | 26 (10.9) | 11 (10.8) | |||
| Creatinine | P=0.497 | 89.93 ± 50.92 | 88.80 ± 31.66 | 0.835 | |
| Normal | 227 (95.0) | 95 (93.1) | |||
| High | 12 (5.0) | 7 (6.9) | |||
| Uric acid | P=0.014 | 359.35 ± 109.90 | 327.06 ± 115.38 | 0.015 | |
| Normal | 190 (79.2) | 92 (90.2) | |||
| High | 50 (20.8) | 10 (9.8) | |||
| Coronary artery lesions | P=0.307 | ||||
| One | 57 (27.9) | 19 (21.3) | / | / | / |
| Two | 39 (19.1) | 23 (25.8) | / | / | / |
| Three or more | 108 (52.9) | 47 (52.8) | / | / | / |
| Gensini score | 54.30 ± 36.03 | 50.98 ± 31.89 | 0.458 | ||
| MALAT1 rs619586 | |||||
| Smoking | P=0.192 | ||||
| No | 88 (30.0) | 20 (39.2) | / | / | / |
| Yes | 205 (70.0) | 31 (60.8) | / | / | / |
| Drinking | P=0.866 | ||||
| No | 215 (73.4) | 38 (74.5) | / | / | / |
| Yes | 78 (26.6) | 13 (25.5) | / | / | / |
| HBP | P=0.569 | ||||
| No | 127 (43.5) | 20 (39.2) | / | / | / |
| Yes | 165 (56.5) | 31 (60.8) | / | / | / |
| Diabetes | P=0.169 | ||||
| No | 222 (75.8) | 34 (66.7) | / | / | / |
| Yes | 71 (24.2) | 17 (33.3) | / | / | / |
| Cerebrovascular disease | P=0.077 | ||||
| No | 256 (87.7) | 40 (78.4) | / | / | / |
| Yes | 36 (12.3) | 11 (21.6) | / | / | / |
| Hyperlipidemia | P=0.434 | ||||
| No | 138 (47.1) | 21 (41.2) | / | / | / |
| Yes | 155 (52.9) | 30 (58.8) | / | / | / |
| Blood glucose | P=0.169 | 8.06 ± 3.80 | 9.10 ± 6.60 | 0.282 | |
| Normal | 90 (31.5) | 20 (40.0) | |||
| High | 195 (68.2) | 29 (58.0) | |||
| Low | 1 (0.3) | 1 (2.0) | |||
| Total cholesterol | P=0.619 | 4.49 ± 1.14 | 4.49 ± 1.56 | 0.965 | |
| Normal | 208 (75.4) | 37 (78.7) | |||
| High | 68 (24.6) | 10 (21.3) | |||
| Triacylglyceride | P=0.003 | 1.82 ± 1.39 | 3.12 ± 3.58 | 0.017 | |
| Normal | 236 (85.5) | 32 (68.1) | |||
| High | 40 (14.5) | 15 (31.9) | |||
| High-density lipoprotein | P=0.150 | 1.02 ± 0.29 | 0.92 ± 0.24 | 0.032 | |
| Normal | 136 (49.3) | 17 (36.2) | |||
| High | 4 (1.4) | 0 (0) | |||
| Low | 136 (49.3) | 30 (63.8) | |||
| Low-density lipoprotein | P=0.572 | 2.97 ± 1.00 | 2.75 ± 1.08 | 0.159 | |
| Normal | 204 (73.9) | 36 (76.6) | |||
| High | 56 (20.3) | 7 (14.9) | |||
| Low | 16 (5.8) | 4 (8.5) | |||
| Urea nitrogen | P=0.077 | 6.22 ± 3.68 | 6.84 ± 5.81 | 0.316 | |
| Normal | 261 (90.6) | 42 (82.4) | |||
| High | 27 (9.4) | 9 (17.6) | |||
| Creatinine | P=0.451 | 90.11 ± 48.60 | 87.03 ± 29.51 | 0.662 | |
| Normal | 273 (94.8) | 47 (92.2) | |||
| High | 15 (5.2) | 4 (7.8) | |||
| Uric acid | P=0.952 | 342.75 ± 101.42 | 385.04 ± 159.87 | 0.013 | |
| Normal | 239 (82.7) | 42 (82.4) | |||
| High | 50 (17.3) | 9 (17.6) | |||
| Coronary artery lesions | P=0.535 | ||||
| One | 66 (26.7) | 14 (31.1) | / | / | / |
| Two | 49 (19.8) | 11 (24.4) | / | / | / |
| Three or more | 132 (53.4) | 20 (44.4) | / | / | / |
| Gensini score | 52.54 ± 33.26 | 54.48 ± 39.14 | 0.727 | ||