Table 3.
Effect of exercise alone or together with Acipimox administration on adipose tissue and plasma metabolites.
| 0 min | 45 min | 45 min | 90 min | 90 min | |
|---|---|---|---|---|---|
| Baseline | Exercise (at 165 min of the experiment) | Exercise (at 165 min of the experiment) | Post-exercise (at 255 min of the experiment) | Post-exercise (at 255 min of the experiment) | |
| +placebo 500 mg p.o. | +OLB 500 mg p.o. | +placebo 500 mg p.o. | +OLB 500 mg p.o. | ||
| AT DIALYSATE EXTRACELLULAR GLYCEROL (μmol/L) | |||||
| HW group (n = 12) | 42.38 ± 3.2 | 85.92 ± 6.62**** | 43.5 ± 2.93++ | 40.38 ± 2.35 | 35.65 ± 2.83* |
| BN group (n = 12) | 31.2 ± 2.85$ | 160.13 ± 14.5****$$ | 36.5 ± 3.66++++ | 33.65 ± 2.17 | 20.17 ± 1.6*$# |
| PLASMA GLYCEROL (μmol/L) | |||||
| HW group (n = 12) | 105.81 ± 14 | 313.2 ± 22**** | 151.7 ± 12.3++ | 81.7 ± 6.6 | 45.4 ± 2.5**# |
| BN group (n = 12) | 77.5 ± 7$ | 193.2 ± 36****$ | 101.3 ± 9.1$+++ | 67.8 ± 4.3 | 48.8 ± 4.4**# |
| PLASMA FFA (mmol/L) | |||||
| HW group (n = 12) | 0.91 ± 0.11 | 1.63 ± 0.06**** | 0.83 ± 0.03+ | 0.78 ± 0.03 | 0.26 ± 0.017****# |
| BN group (n = 12) | 0.74 ± 0.08$ | 1.87 ± 0.16****$ | 0.76 ± 0.08+ | 0.88 ± 0.15 | 0.24 ± 0.015****# |
| INSULIN (mIU/L) | |||||
| HW group (n = 12) | 5.21 ± 0.79 | 4.05 ± 0.26 | 2.99 ± 0.42*+ | 2.51 ± 0.19* | 2.48 ± 0.28* |
| BN group (n = 12) | 2.38 ± 0.33$$ | 2.12 ± 0.37$$ | 1.78 ± 0.33* | 1.71 ± 0.24* | 0.76 ± 0.23**$# |
| GLUCOSE (mmol/L) | |||||
| HW group (n = 12) | 4.69 ± 0.09 | 4.45 ± 0.19 | 4.79 ± 0.11 | 4.61 ± 0.13 | 4.36 ± 0.14 |
| BN group (n = 12) | 4.2 ± 0.12 | 4.41 ± 0.24 | 5.6 ± 0.20**+ | 3.72 ± 0.19 | 4.62 ± 0.18 |
Values are means ± S.E.M. HW, healthy-weight Czech women; BN, Czech women with bulimia nervosa, n = the numbers of subjects are in brackets.
P < 0.05,
P < 0.01,
P < 0.0001 vs. resting (basal) values.
P < 0.05 BN vs. HW.
P < 0.01 BN vs. HW.
P < 0.05 exercise together with OLB administration vs. exercise alone, 45min.
P < 0.01 exercise together with OLB administration vs. exercise alone, 45 min.
P < 0.001 exercise together with OLB administration vs. exercise alone, 45 min.
P < 0.0001 exercise together with OLB administration vs. exercise alone, 45 min.
P < 0.05 post-exercise recovering phase together with OLB administration vs. post-exercise recovering phase alone, 90 min.
Effect of 45 min exercise (at 165 min after the start of the experiment, 2 W/kg of lean body mass [LBM]) and effect of 90 min post-exercise recovery phase (at 255 min after the start of the experiment) alone or together with Acipimox (OLB) administration on adipose tissue (AT) glycerol and plasma glycerol levels, plasma free fatty acids (FFA), blood glucose, and plasma insulin levels in healthy-weight Czech women (HW) (n = 12), and in Czech women with bulimia nervosa (BN) (n = 12).