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. 2019 Mar 12;10:179. doi: 10.3389/fphys.2019.00179

Figure 2.

Figure 2

Performance of female (A,C) and male (B,D) mice that received sham irradiation or mixed beams in the open field (A,B) and the novel object recognition (C,D) tests. (A/B) The female and male mice habituated to the open field. The distance traveled decreased over the 3 days of exposure to the open field (Mauchly’s test of sphericity: p = 0.181, Greenhouse–Geisser corrected, F 1.917,149.509 = 77.654; p < 0.001) and female mice showed higher activity levels than male mice (F 1,78 = 7.387; p = 0.008). In addition, there was an effect of radiation on activity levels (F 1,78 = 3.860; p = 0.012). Mice irradiated with 25 cGy showed higher activity levels than mice irradiated with 200 cGy (p = 0.010, t test). (C/D) Female (C) and male (D) sham-irradiated mice and those irradiated at the 25 cGy preferentially explored the novel object (females sham-irradiated mice: p = 0.00047; female mice irradiated with 25 cGy: p = 0.019; male sham-irradiated mice: p = 0.0023; male mice irradiated with 25 cGy: p < 0.0001, t tests) but female (C) and male (D) mice irradiated with 50 or 200 cGy were impaired and did not.