Table 1.
Summary of studies investigating near-infrared fluorescence guided neurosurgery with second-window ICG.
| References | Tumor type (n) | Sensitivity (WL, NIR) | Specificity (WL, NIR) | PPV (WL, NIR) | NPV (WL, NIR) |
|---|---|---|---|---|---|
| Lee et al. (49) | Gliomas (15) | 84% 98% |
80% 45% |
92% 82% |
67% 90% |
| Lee et al. (50) | Metastases (13) | 82% 96% |
91% 27% |
96% 77% |
67% 75% |
| Lee et al. (51) | Meningiomas (18) | 82% 96% |
100% 39% |
100% 71% |
78% 88% |
| Cho et al. (52) | Varied (6) | NA | NA | NA | NA |
| Jeon et al. (53) | Skull-base Tumors (15) | NA | NA | NA | NA |
| Cho et al. (54) | Pituitary Adenomas (16) | 88% 100% |
90% 29% |
96% 82% |
73% 100% |
NA, Not applicable; NIR, Near-infrared; NPV, Negative-predictive value; PPV, Positive-predictive value; WL, White-light.