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. 2019 Mar 12;10:152. doi: 10.3389/fendo.2019.00152

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Copyright © 2019 Li, Zhang, Xu, Zhao, Mahanand, Zhu, Deng, Nevo, Du and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of Mut-p53 aggravate malignant behaviors in endocrine cancers. Blue sector represents Mut-p53-mediated EMT process. Gray sector represents Non-EMT metastasis. Purple sector indicates Mut-p53-regulated PD-L1 immune evasion in cancer cells. Red triangle indicates the inhibitors for current research. PDGFRb, platelet-derived growth factor receptor b; NF/Y, nuclear factors; NRP2, Neuropilin-2; DLX2, Distal-less homeobox 2; TGF-β, transforming growth factor β; EGFR, Epidermal growth factor receptor; RCP, Rab-coupling protein; Myo10, Myosin-X; Rac1, Ras-related C3 botulinum toxin substrate 1; SENP1, SUMO-specific protease 1; miR-34, miRNA 34; miR-200, miRNA 200; NRF2, Nuclear factor-like 2; miR-30c, miRNA 30c; KSRP, KH-type splicing regulatory protein; Rad21, Double-strand-break repair protein rad21; S1PR1, Sphingosine-1-phosphate receptor 1; THBS1, Thrombospodin 1; PD-L1, programmed death-ligand 1.