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Summary of the important cells and tissues required to mediate HSC expansion through evolution.
| Drosophila (Lymph gland) | Zebrafish (CHT) | Xenopus (FL) | Chicken (PAF +YS) | Mammals (FL) | |
|---|---|---|---|---|---|
| HSC Progeny | Yes | ? | ? | ? | ? |
| Stromal cells | Yes | Yes | Yes | Yes | Yes |
| Endothelial cells | No | Yes | Yes | Yes (YS) | Yes |
| Hepatocytes | No | No | ? | No | Yes |
| Nervous system | ? | ? | ? | ? | ? |
CHT, caudal hematopoietic tissue; FL, fetal liver; PAF, para-aortic foci; YS, yolk sac.
