Figure 2.

Representative images illustrating sortilin IR in the primary motor (precentral gyrus), somatosensory (postcentral gyrus), and visual cortices of adult human brain. Cortical regions and lamination are as indicated in individual panels. Note the narrow layer IV (A) and V (B) in the motor and somatosensory areas, respectively. In the hematoxylin-counterstained sections, large pyramidal neurons with heavy IR are clearly present in the low portion of layer III, whereas layer IV has few labeled cells (C,D). In the occipital cortex, the border between areas 17 and 18 can be identified based on the widening and stratification of layer IV in the former (E). Again, sortilin IR occurs mainly in layers II/III and VI (F), with those in layers II/III localized to pyramidal neurons (G). Note that the layer V of area 17 is thin, whereas layer IV is expanded and can be divided into IVa, IVb, IVcα, and IVcβ based on the difference in labeling intensity (F). CS, calcarine sulcus. Scale bars are as indicated.