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. 2019 Mar 12;13:31. doi: 10.3389/fnana.2019.00031

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Copyright © 2019 Xu, Zhang, Zhang, Wan, Jiang, Tu, Manavis, Pan, Cai and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Images showing sortilin IR in subregions of the basal ganglia. Panel (A) is a low power view of frontal section at the level of the insular lobe, with framed areas enlarged as other panels as marked. Compared to the strong labeling in the insular cortex (iCtx) and the claustrum nucleus (Cla), light to moderate IR is seen in the body of caudate (CaB), the putamen (Pu) and globus pallidus (GP). At higher magnifications, the labeled cells in the above areas are mostly small multipolar neurons exhibiting light to moderate intensity. However, individual large-sized multipolar neurons are heavily labeled (B,C,D,F,G,H). Panels (E,I) show high power views of the cells in the Cla, which exhibit stronger labeling intensity relative to the labeled neurons in the striatum. Note the lack of sortilin IR in the internal (IC) and external (EC) capsules. LS, lateral sulcus. Scale bars are as indicated.