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. 2019 Mar 12;13:31. doi: 10.3389/fnana.2019.00031

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Copyright © 2019 Xu, Zhang, Zhang, Wan, Jiang, Tu, Manavis, Pan, Cai and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low (A) and high (B–F) power views of sortilin IR in the adult human medulla oblongata (MO). At low magnification, labeled elements are mainly arranged as groups of cells located medial and lateral to the fourth ventricle (4V), and in the ventrolateral areas of the pons corresponding to the main and accessory nuclei (dorsal and medial, IOd and IOm) of the inferior olive (IO). Thus, labeled neurons are located in all cranial nerve nuclei at this level, including the cochlear and vestibular nuclei (8N), dorsal motor nucleus of vagus (10N), hypoglossal nucleus (12N), facial nucleus (7N), trigeminal sensory nucleus (5N), the solitary tract nucleus (SoN) and the reticular formation (RF) (B–D). Neurons in the arcuate nucleus (AN) are also labeled, whereas the pyramid (Py) is unlabeled (A). Labeled neurons in the IO are mostly multipolar in shape by closer examination (E,F). Scale bars are as indicated in the panels.