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. 2019 Mar 12;13:16. doi: 10.3389/fninf.2019.00016

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Copyright © 2019 Kochunov, Patel, Ganjgahi, Donohue, Ryan, Hong, Chen, Adhikari, Jahanshad, Thompson, Van’t Ent, den Braber, de Geus, Brouwer, Boomsma, Hulshoff Pol, de Zubicaray, McMahon, Martin, Wright and Nichols.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histograms for the dataset that showed reduced heritability estimates for fast vs. MLE based heritability estimation approaches. APACE showed reduced heritability estimates in superior corona-radiata-right (SCR-L) and SLF-L tracts in the human connectome project (HCP) cohort due to deviations from normal distribution (top panel). FPHI showed reduced heritability estimates in the externalcapsule-right (EC-R) and inferior fronto-occipital tract-left (IFO-L) tracts in the HCP cohort due to the high kurtosis and non-Gaussian shape of the histograms for EC-R and IFO-L, respectively.