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. 2019 Feb 13;79(4):365–379. doi: 10.1007/s40265-019-1064-1

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© The Author(s) 2019, corrected publication 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Timeline of landmark randomised trials comparing standard with intensive blood pressure control. ACEi angiotensin converting enzyme inhibitor, BP blood pressure, CCB calcium channel antagonist (blocker), CVD cardiovascular disease, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, ESRD end-stage renal disease, MAP mean arterial pressure, MDRD Modification of Diet in Renal Disease, SBP systolic blood pressure, T2DM type 2 diabetes mellitus