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. 2018 Dec 17;174(2):505–514. doi: 10.1007/s10549-018-05090-y

Table 2.

Stage I–III breast cancer w/out distant relapse versus stage I–III with subsequent distant relapse (n = 8292)

Stage I–III rMBC p value
(n = 7328) (n = 964)
N (%) N (%)
Stage
 I 4036 (55%) 163 (17%) < 0.001
 II 2688 (37%) 447 (46%)
 III 604 (8%) 354 (37%)
Age
 20–39 497 (7%) 140 (15%) < 0.001
 40–49 1680 (23%) 250 (26%)
 50–69 3660 (50%) 428 (44%)
 70–79 1071 (15%) 118 (12%)
 80+ 420 (6%) 28 (3%)
Mean age (range and significance of F statistic) 58 (21–94) 54 (23–93) < 0.001
Race
 White 6267 (86%) 842 (87%) 0.142
 Non-white 1061 (14%) 122 (13%)
Diagnosis year primary breast cancer
 1990–1998 1917 (26%) 455 (47%) < 0.001
  (row totals) (81%) (19%)
 1999–2004 2128 (29%) 260 (27%)
  (row totals) (89%) (11%)
 2005–2011 3283 (45%) 249 (26%)
  (row totals) (93%) (7%)
Initial breast tumor detection method
 By patient or physician (symptomatic) 3322 (46%) 706 (74%) < 0.001
 By mammography 3906 (54%) 244 (26%)
Hormone receptor status at initial diagnosis (n = 8169)
 HR+ 6182 (86%) 703 (74%) < 0.001
HER2 status at initial diagnosis (n = 5475)*
 HER2+ (HR− or HR+) 690 (14%) 80 (17%) 0.07
HR/HER2 status at initial diagnosis (n = 5470)*
 HR+/HER2− 3830 (77%) 287 (60%) < 0.001
 HR+/HER2+ 476 (10%) 53 (11%)
 HR−/HER2− 475 (10%) 108 (23%)
 HR−/HER2+ 214 (4%) 27 (6%)
Histologic type primary breast tumor
 Ductal 5924 (81%) 780 (81%) 0.005
 Lobular 672 (9%) 113 (12%)
 Lobular/ductal mixed 336 (5%) 37 (4%)
 Other cancer 396 (5%) 34 (4%)
Nuclear grade initial primary breast tumor
 Low/intermediate 4207 (60%) 357 (41%) < 0.001
 High 2802 (40%) 530 (59%)
Histologic grade initial primary breast tumor
 Low/intermediate 2492 (36%) 196 (22%) < 0.001
 High 4465 (64%) 703 (78%)
Tumor size (mean, range, and significance of F statistic) 1.98 cm (0.1–21 cm) 3.67 cm (0.1–20 cm) < 0.001
Number of positive lymph nodes (mean, range, and significance of F statistic) 0.93 (0–44) 4.44 (0–36) < 0.001

*Trastuzumab FDA approval 1998, consistent HER2 testing began in 1999