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. 2019 Mar 12;10:259. doi: 10.3389/fphar.2019.00259

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Copyright © 2019 Liu, Zhang, Shen, Ding, Yang, Zhang, Li, Deng, Gong, Liu, Qian and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Magnetic Resonance Imaging (MRI) of the proband and the two-generation pedigree. (A,B) Brain MRI of the proband at the age of 10 months showed deep sulci in the frontal and parietal lobes and a wide subarachnoid space. (C) The two-generation pedigree of the family with CMS-EA. The parents are unaffected, while the two offspring are affected. The arrow indicates the proband.