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. 2019 Mar 12;10:259. doi: 10.3389/fphar.2019.00259

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Copyright © 2019 Liu, Zhang, Shen, Ding, Yang, Zhang, Li, Deng, Gong, Liu, Qian and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram for the mutant CHAT proteins. (A) The ChAT protein with c.914T>C (p.Ile305Thr) variant. (B) The ChAT protein with the large deletion from the 4th to 6th exons. The red box indicates the acetyl coenzyme -dependent acyltransferase domain.