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. 2019 Mar 18;9:4696. doi: 10.1038/s41598-019-41140-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cordycepin treatment reduces established knee joint pain and synovial inflammation in the DMM model of OA. OA was induced on day 0 by surgically displacing the medial meniscus (DMM). Sham-operated mice were used as controls in which the ligament was visualised but not transected. Cordycepin or vehicle was given orally for a period of 2 weeks, starting at week 14 when knee joint pain measured as weightbearing asymmetry (A) was first evident in the DMM operated mice. Sham-operated mice did not exhibit joint pain. Cordycepin (cordy) treatment reduced the established pain behavior observed following DMM surgery (A). Fresh frozen synovial tissues were dissected at week 16 and synovial tissue mRNA expression analysed for inflammatory (B; CD68 and E; IL1β) and angiogenic (C; nestin and F; VEGF) markers with no alteration in cell proliferation (D; PCNA and G; MYC) markers. Data are mean ± SEM of n = 15 mice per group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus sham controls. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus DMM + Cordy group.