Table 2.
KRASG12D | p53R167H | SMAD4 shRNA | p16Ink4A shRNA | Colony formation | Proliferation | Migration | Invasion | Xenografts | |
---|---|---|---|---|---|---|---|---|---|
PGKP | + | + | +++ | + | |||||
PGKPS | + | + | + | ++ | +++ | + | ++ | + | |
PGKPSC | + | + | + | + | +++ | +++ | + | ++ | + |
P, porcine epithelial cells; G, GFP; K, KRASG12D; P, p53R167H; S, SMAD4; C, CDKN2A/p16. Transformed phenotypes of porcine pancreatic ductal epithelial cells in vitro and in vivo. Scale of transformation +++ > ++ > +.