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. 2019 Mar 12;9:144. doi: 10.3389/fonc.2019.00144

Table 2.

Characteristics of transformed porcine ductal epithelial cells [data published as preprint (77)].

KRASG12D p53R167H SMAD4 shRNA p16Ink4A shRNA Colony formation Proliferation Migration Invasion Xenografts
PGKP + + +++ +
PGKPS + + + ++ +++ + ++ +
PGKPSC + + + + +++ +++ + ++ +

P, porcine epithelial cells; G, GFP; K, KRASG12D; P, p53R167H; S, SMAD4; C, CDKN2A/p16. Transformed phenotypes of porcine pancreatic ductal epithelial cells in vitro and in vivo. Scale of transformation +++ > ++ > +.