Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 12;10:438. doi: 10.3389/fimmu.2019.00438

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Pilzecker and Jacobs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Detailed model of ncMMR in A/T mutagenesis. After U induction by AID, UNG2 processes U into an abasic site. In this more detailed model of ncMMR there are to arm on ncMMR, (1) UNG2 and APEX2 provide the incision for EXO1. EXO1 requires MSH2/6 and a 5' gap to the mismatch to be generate single-stranded DNA. PCNA-Ub recruits POLH, which can fill in the single-stranded DNA gap. (2) MSH2/MSH6 complex recognizes mismatch and activate the PMS2/MLH1 complex to make the incision. EXO1 creates singles stranded DNA gap, which is filled in by POLH.