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. 2019 Mar 12;10:438. doi: 10.3389/fimmu.2019.00438

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Copyright © 2019 Pilzecker and Jacobs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The potential but unlikely role of pre/mRNA in A/T mutagenesis. As the pre/mRNA is copied from the non-coding strand, it can only act as template for repair synthesis on the non-coding strand. After the pre/mRNA is copied from the non-coding strand, a gap can arise in the DNA-RNA hybrid on the non-coding DNA strand. As POLH has reverse transcriptase activity, this gap will be filled in an error-prone manner by POLH. However, if this potential mechanism or any other mechanism using the cDNA as an intermediate would be a dominant mode, a higher rate of T mutations compared to A mutations is expected, which directly contrasts the observed A/T bias.