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. 2019 Mar 12;9:140. doi: 10.3389/fonc.2019.00140

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Copyright © 2019 Piazzi, Prossomariti, Baldassarre, Montagna, Vitaglione, Fogliano, Biagi, Candela, Brigidi, Balbi, Munarini, Belluzzi, Pariali, Bazzoli and Ricciardiello.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of MD-MIX on tumor multiplicity, size and histological distribution of colonic lesions. (A) Representative images of colons fixed in Bouin's solution; (B) Tumor multiplicity (number of macroscopic lesions/mouse) (ANOVA p = 0.0027); (C) Number of macroscopic colonic lesions by size (ANOVA p = 0.0052 for lesions >1 mm); (D) Number of low grade dysplasia (LGD) lesions/mouse (ANOVA p = 0.0329); (E) Number of high grade dysplasia+ adenocarcinoma lesions (HGD+adenoK)/mouse. Data are shown as individual values. n = 8 LFD; n = 10 LFD-MD-MIX; n = 6 HFWD; n = 7 HFWD-MD-MIX. P-values were determined using one-way two-tailed ANOVA followed by Tukey's multiple comparison post-hoc test. ^§p < 0.05 vs. LFD; ^°°p < 0.01 vs. LFD-MD-MIX; ⁺p < 0.05 vs. HFWD.