FIGURE 3.

Contribution of TRPM2 channel-mediated neuroinflammation in CNS pathologies. Summary of the key events in TRPM2-mediated neuroinflammation implicated in various CNS pathologies. Activation of the TRPM2 channel in microglial cells mediates microglial cell activation, generation of proinflammatory mediators and/or neuroinflammation that have been shown to contribute to the pathogenesis of neuropathic pain, brain damage by chronic cerebral hypo-perfusion and neonatal hypoxia-ischemia, and Aβ-induced AD. CNS, central nervous system; Aβ, amyloid β peptides; AD, Alzheimer’s disease.