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. 2019 Mar 12;13:215. doi: 10.3389/fnins.2019.00215

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Copyright © 2019 Min, Kim, Jung, Lee, Kim, Chae, Lee and Park.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design and experimental procedures: (A) In Study 1, after resting, baseline skin blood perfusion and HRV were obtained for 5 min and intervention was subsequently performed on the non-dominant side. Skin blood perfusion and HRV were obtained (A1 and A2 phase) for 10 min. After itch induction, HRV, skin blood perfusion, and itch intensity were measured for 10 min (H1 and H2 phase). The intervention was removed and skin blood perfusion, HRV, and itch intensity were obtained (H3 and H4 phase). (B) In Study 2, after 15 min resting, participants underwent three fMRI scanning sessions. Scans for each session were for 4-min baseline resting state, intervention (A, 5 min), and itch resting state (H1, 0–4; H2, 4–8 min). HRV, heart rate variability; s, seconds; min, minutes; fMRI, functional magnetic resonance imaging.