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. 2019 Mar 12;13:215. doi: 10.3389/fnins.2019.00215

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Copyright © 2019 Min, Kim, Jung, Lee, Kim, Chae, Lee and Park.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional connectivity of the putamen and pMCC and correlation with connectivity and itch intensity for acupuncture treatment between responder and non-responder groups: (A) Seed was putamen, (B) Seed-based functional connectivity from the putamen, showing a significant cluster in the midcingulate cortex (X = –6, Y = 0, Z = 40), (C) Change in functional connectivity from baseline resting state to histamine-induced itch state in responders (top) and non-responders (bottom), (D) Graph shows differences in connectivity from baseline to itch as a function of differences in perceived itch intensity from baseline to itch, as reported by participants for each scan session.