Figure 8.

Distinct regional distributions of MUC5AC, MUC5B, and CCSP mRNA localization in superficial epithelium of the normal/healthy lung. Data represent the calculated percent of total MUC5AC, MUC5B, or CCSP mRNA–stained volumes for each airway region. Total MUC5AC, MUC5B, or CCSP mRNA–stained volume for each airway region was calculated by multiplying the mean values of the RNA in situ hybridization volume densities for each airway region obtained from five normal/healthy lungs by predicted total surface area of corresponding airway regions. CCSP = club cell secretory protein.